Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

4 Oct 2016

Abstract excerpt

Proteolysis of autoantigens can alter normal MHC class II antigen processing and has been implicated in the induction of autoimmune diseases. Many autoantigens are substrates for the protease granzyme B (GrB), but the mechanistic significance of this association is unknown. Peptidylarginine deiminase 4 (PAD4) is a frequent target of autoantibodies in patients with rheumatoid arthritis (RA) and a substrate for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27700100
DOI: 10.1021/acs.jproteome.6b00617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid ArthritisPMID 27700100Read ↗

PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets.Semantic proximity Read ↗

Granzyme K drives a newly-intentified pathway of complement activationSemantic proximity Read ↗

Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.Semantic proximity Read ↗

Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4Semantic proximity Read ↗

Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritisSemantic proximity Read ↗

Peptidylarginine deiminase 4 and citrullination in health and disease.Semantic proximity Read ↗

Consequence of neo-antigenicity of the 'altered self'.Semantic proximity Read ↗

Citrullinated proteins in rheumatoid arthritis.Semantic proximity Read ↗

In silico degradomics reveals disease- and endotype-specific alterations in the joint tissue landscapeSemantic proximity Read ↗

Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles.Semantic proximity Read ↗

The Role of Conformational Dynamics in Antigen Trimming by Intracellular AminopeptidasesSemantic proximity Read ↗

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.