Article
Phenotype and influx kinetics of leukocytes and inflammatory cytokine production in kidney ischemia/reperfusion injury.
Nephrology (Carlton, Vic.) - 1 Jan 2018
Williams Timothy M, Wise Andrea F, Layton Daniel S, Ricardo Sharon D
Abstract excerpt
BACKGROUND AND AIM: Kidney ischemia/reperfusion (IR) injury is characterized by tubular epithelial cell (TEC) death and an inflammatory response involving cytokine production and immune cell infiltration. In various kidney diseases, increased macrophage numbers correlate with injury severity and poor prognosis. However, macrophage plasticity enables a diverse range of functions, including wound healing, making...
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