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Article

Involvement of Macrophages in the Pathogenesis of Familial Amyloid Polyneuropathy and Efficacy of Human iPS Cell-Derived Macrophages in Its Treatment.

PloS one - 1 Jan 2016

Suenaga Genki, Ikeda Tokunori, Komohara Yoshihiro, Takamatsu Koutaro, Kakuma Tatsuyuki, Tasaki Masayoshi, Misumi Yohei, Ueda Mitsuharu, Ito Takaaki, Senju Satoru, Ando Yukio

Abstract excerpt

We hypothesized that tissue-resident macrophages in familial amyloid polyneuropathy (FAP) patients will exhibit qualitative or quantitative abnormalities, that may accelerate transthyretin (TTR)-derived amyloid deposition. To evaluate this, we examined the number and subset of tissue-resident macrophages in heart tissue from amyloid-deposited FAP and control patients. In both FAP and control patients,...

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Topics

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Share to Amyloid Neuropathies, Familial
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Lectins, C-Type

Share to Mannose-Binding Lectins

Share to Mannose Receptor

Share to Prealbumin

Share to Protein Aggregation, Pathological

Source

Open in PubMed Open full text

Identifiers

PMID: 27695122
DOI: 10.1371/journal.pone.0163944
PMCID: PMC5047455

Genes

FAP
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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