Article
Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.
G3 (Bethesda, Md.) - 7 Dec 2016
Chesler Elissa J, Gatti Daniel M, Morgan Andrew P, Strobel Marge, Trepanier Laura, Oberbeck Denesa, McWeeney Shannon, Hitzemann Robert, Ferris Martin, McMullan Rachel, Clayshultle Amelia, Bell Timothy A, Manuel de Villena Fernando Pardo, Churchill Gary A
Abstract excerpt
Multi-parent populations (MPPs) capture and maintain the genetic diversity from multiple inbred founder strains to provide a resource for high-resolution genetic mapping through the accumulation of recombination events over many generations. Breeding designs that maintain a large effective population size with randomized assignment of breeders at each generation can minimize the impact of selection, inbreeding,...
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