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Article

Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways.

Cancer letters - 28 Dec 2016

Xu Peng, Dang Yongyan, Wang Luyang, Liu Xia, Ren Xiaolin, Gu Jun, Liu Mingyao, Dai Xing, Ye Xiyun

Abstract excerpt

Lgr4 is a member of the leucine-rich, G protein-coupled receptor family of proteins, and has recently been shown to augment Wnt/β-catenin signaling via binding to Wnt agonists R-spondins. It plays an important role in skin development, but its involvement in skin tumorigenesis is unclear. Here, we report that mice deficient for Lgr4 are resistant to 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced keratinocyte...

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Identifiers

PMID: 27693558
DOI: 10.1016/j.canlet.2016.09.005
PMCID: PMC8549826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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