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Article

LTA4H regulates cell cycle and skin carcinogenesis

25 May 2017

Abstract excerpt

Leukotriene A4 hydrolase (LTA4H), a bifunctional zinc metallo-enzyme, is reportedly overexpressed in several human cancers. Our group has focused on LTA4H as a potential target for cancer prevention and/or therapy. In the present study, we report that LTA4H is a key regulator of cell cycle at the G0/G1 phase acting by negatively regulating p27 expression in skin cancer. We found that LTA4H is overexpressed in...

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Identifiers

PMID: 28575166
DOI: 10.1093/carcin/bgx049

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