Article
RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation.
Current biology : CB - 20 Aug 2002
Holland Pamela, Willis Cynthia, Kanaly Suzanne, Glaccum Moira, Warren Annjanette, Charrier Keith, Murison J, Derry Jonathan, Virca G, Bird Timothy, Peschon Jacques
Abstract excerpt
The epidermis is a stratified, continually renewing epithelium dependent on a balance among cell proliferation, differentiation, and death for homeostasis. In normal epidermis, a mitotically active basal layer gives rise to terminally differentiating keratinocytes that migrate outward and are ultimately sloughed from the skin surface as enucleated squames. Although many proteins are known to function in...
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