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Article

Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype.

EMBO reports - 1 Aug 2005

Ballarò Costanza, Ceccarelli Sara, Tiveron Cecilia, Tatangelo Laura, Salvatore Anna Maria, Segatto Oreste, Alemà Stefano

Abstract excerpt

Although it has been clearly established that negative feedback loops have a fundamental role in the regulation of epidermal growth factor receptor (EGFR) signalling in flies, their role in the regulation of mammalian EGFR has been inferred only recently from in vitro studies. Here, we report on the forced expression of RALT/MIG-6, a negative feedback regulator of ErbB receptors, in mouse skin. A RALT transgene...

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Source

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Identifiers

PMID: 16007071
DOI: 10.1038/sj.embor.7400458
PMCID: PMC1369136

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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