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Article

ADAR1 regulates <i>ARHGAP26</i> gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding

25 Sept 2013

Abstract excerpt

Rho GTPase activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that converts the small G proteins RhoA and Cdc42 to their inactive GDP-bound forms. It is essential for the CLIC/GEEC endocytic pathway, cell spreading, and muscle development. The present study shows that ARHGAP26 mRNA undergoes extensive A-to-I RNA editing in the 3' UTR that is specifically catalyzed by ADAR1. Furthermore,...

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Identifiers

PMID: 24067935
DOI: 10.1261/rna.041533.113

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