Article
Regulation of divalent metal transporter-1 by serine phosphorylation.
The Biochemical journal - 15 Nov 2016
Seo Young Ah, Kumara Ruvin, Wetli Herbert, Wessling-Resnick Marianne
Abstract excerpt
Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome. Here, we report that classical cannabinoids (Δ9-tetrahydrocannabinol, Δ9-THC), nonclassical cannabinoids (CP 55,940), aminoalkylindoles (WIN 55,212-2) and endocannabinoids (anandamide) reduce 55Fe and 54Mn uptake by HEK293T(DMT1) cells...
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