Article
Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.
Biochemical and biophysical research communications - 28 Mar 2003
Voskoboinik I, Fernando R, Veldhuis N, Hannan K M, Marmy-Conus N, Pearson R B, Camakaris J
Abstract excerpt
The Menkes copper-translocating P-type ATPase (ATP7A; MNK) is a key regulator of copper homeostasis in humans. It has a dual role in supplying copper to essential cuproenzymes in the trans-Golgi network (TGN) and effluxing copper from the cell. These functions are achieved through copper-regulated trafficking of MNK between the TGN and the plasma membrane. However, the exact mechanism(s) which regulate the...
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