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Article

Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells

1 Sept 2006

Abstract excerpt

Zip14 is a member of the SLC39A zinc transporter family, which is involved in zinc uptake by cells. Up-regulation of Zip14 by IL-6 appears to contribute to the hepatic zinc accumulation and hypozincemia of inflammation. At least three members of the SLC39A family transport other trace elements, such as iron and manganese, in addition to zinc. We analyzed the capability of Zip14 to mediate non-transferrin-bound...

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PMID: 16950869
DOI: 10.1073/pnas.0606424103

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