Article
Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes.
Pflugers Archiv : European journal of physiology - 1 Jan 2006
Mackenzie Bryan, Ujwal M L, Chang Min-Hwang, Romero Michael F, Hediger Matthias A
Abstract excerpt
The H(+) -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol in erythroid precursors and other cells. Elucidating the molecular mechanisms of DMT1 will therefore increase our understanding of iron metabolism and the etiology of iron...
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