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Article

DNA looping provides stability and robustness to the bacteriophage lambda switch.

Proceedings of the National Academy of Sciences of the United States of America - 19 May 2009

Morelli Marco J, Ten Wolde Pieter Rein, Allen Rosalind J

Abstract excerpt

The bistable gene regulatory switch controlling the transition from lysogeny to lysis in bacteriophage lambda presents a unique challenge to quantitative modeling. Despite extensive characterization of this regulatory network, the origin of the extreme stability of the lysogenic state remains unclear. We have constructed a stochastic model for this switch. Using Forward Flux Sampling simulations, we show that...

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Share to Bacteriophage lambda
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Switch

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Share to Operator Regions, Genetic

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Source

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Identifiers

PMID: 19416825
DOI: 10.1073/pnas.0810399106
PMCID: PMC2686219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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