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Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

26 Sept 2016

Abstract excerpt

A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased...

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PMID: 27666519
DOI: 10.1038/ncomms12910

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