Article

A unifying functional dichotomy organises breast cancer molecular landscape, resolves PIK3CA ambiguity, and supports tiered tumour classification

2026-03-02

Abstract excerpt

Clinical interpretation of breast cancer sequencing is constrained not by a lack of data but by the absence of an organising framework that translates constellations of co-occurring mutations and copy-number alterations into tumour-level biology with prognostic and therapeutic meaning. This challenge is exemplified by PIK3CA, a clinically actionable alteration often treated as a single-label biomarker despite cont...

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Literature Corpus work: 82d7547d-6a88-5e08-a794-db2680180777
DOI: 10.64898/2026.02.22.26346715

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