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Article

TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.

Molecular cancer research : MCR - 1 Dec 2008

Zhang Yaqin, Zhang Baolin

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agnostic antibodies, which are being evaluated clinically as anticancer therapies, selectively kill cancer cells through the death receptors DR4 and DR5. However, their therapeutic potential is limited by occurring resistance in tumor cells. Here, we compared the apoptotic response of a panel of six human breast cancer cell lines with...

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Source

Identifiers

PMID: 19074831
DOI: 10.1158/1541-7786.MCR-08-0313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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