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Article

Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

29 Mar 2008

Abstract excerpt

Targeting TRAIL receptors with either recombinant TRAIL or agonistic DR4- or DR5-specific antibodies has been considered a promising treatment for cancer, particularly due to the preferential apoptotic susceptibility of tumor cells over normal cells to TRAIL. However, the realization that many tumors are unresponsive to TRAIL treatment has stimulated interest in identifying apoptotic agents that when used in...

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PMID: 18375389
DOI: 10.1074/jbc.m710169200

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