Article
TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways.
Brain pathology (Zurich, Switzerland) - 1 Oct 2003
Song Jin H, Song Doyoun K, Pyrzynska Beata, Petruk Kenneth C, Van Meir Erwin G, Hao Chunhai
Abstract excerpt
Many malignant glioma cells express death receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), yet some of these cells are resistant to TRAIL. Here, we examined signaling events in TRAIL-induced apoptosis and searched for therapeutic agents that could overcome TRAIL resistance in glioma cells. TRAIL induced apoptosis through death receptor 5 (DR5) and was mediated by caspase-8-initiated...
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