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Article

Reduced DNA methylation of FKBP5 in Cushing's syndrome.

Endocrine - 1 Dec 2016

Resmini Eugenia, Santos Alicia, Aulinas Anna, Webb Susan M, Vives-Gilabert Yolanda, Cox Olivia, Wand Gary, Lee Richard S

Abstract excerpt

FKBP5 encodes a co-chaperone of HSP90 protein that regulates intracellular glucocorticoid receptor sensitivity. When it is bound to the glucocorticoid receptor complex, cortisol binds with lower affinity to glucocorticoid receptor. Cushing's syndrome is associated with memory deficits, smaller hippocampal volumes, and wide range of cognitive impairments. We aimed at evaluating blood DNA methylation of FKBP5 and...

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Identifiers

PMID: 27664120
DOI: 10.1007/s12020-016-1083-6
PMCID: PMC6391874

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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