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Article

DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans.

Molecular psychiatry - 1 May 2024

Yusupov Natan, Roeh Simone, Sotillos Elliott Laura, Chang Simon, Loganathan Srivaishnavi, Urbina-Treviño Lidia, Fröhlich Anna S, Sauer Susann, Ködel Maik, Matosin Natalie, Czamara Darina, Deussing Jan M, Binder Elisabeth B

Abstract excerpt

Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in the context of gene x environment interactions, have not yet been explored in humanized mouse models. We applied high-accuracy measurement of DNA methylation (DNAm) via targeted bisulfite sequencing (HAM-TBS) to...

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Source

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Identifiers

PMID: 38317011
DOI: 10.1038/s41380-024-02430-x
PMCID: PMC11189813

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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