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Article

Reduced DNA methylation and psychopathology following endogenous hypercortisolism – a genome-wide study

16 Mar 2017

Abstract excerpt

Patients with Cushing's Syndrome (CS) in remission were used as a model to test the hypothesis that long-standing excessive cortisol exposure induces changes in DNA methylation that are associated with persisting neuropsychological consequences. Genome-wide DNA methylation was assessed in 48 women with CS in long-term remission (cases) and 16 controls matched for age, gender and education. The Fatigue impact...

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PMID: 28300138
DOI: 10.1038/srep44445

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