Article
The South American Plasmodium falciparum var gene repertoire is limited, highly shared and possibly lacks several antigenic types.
Gene - 15 Mar 2010
Albrecht Letusa, Castiñeiras Catarina, Carvalho Bruna O, Ladeia-Andrade Simone, Santos da Silva Natal, Hoffmann Erika H E, dalla Martha Rosimeire C, Costa Fabio T M, Wunderlich Gerhard
Abstract excerpt
The Plasmodium falciparum var gene family encodes large variant antigens, which are important virulence factors, and also targets of the humoral host response. The frequently observed mild outcomes of falciparum malaria in many places of the Amazon area prompted us to ask whether a globally restricted variant (var) gene repertoire is present in currently circulating and older isolates of this area. By exhaustive...
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