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Article

NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton.

Frontiers in immunology - 1 Jan 2021

Lee E Hui Clarissa, Wong Darren Chen Pei, Ding Jeak Ling

Abstract excerpt

Natural killer (NK) cells are innate immune cells which play a key role in shaping the immune response against cancer. Initially hailed for their potential to recognise and eliminate tumour cells, their application has been greatly hindered by the immunosuppressive tumour microenvironment (TME) which suppresses NK functions (e.g., cytotoxicity). This dysfunctional state that is accompanied by phenotypic changes...

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Topics

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Share to Cytoskeleton
Share to Cytotoxicity, Immunologic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lymphocytes, Tumor-Infiltrating

Share to Mechanotransduction, Cellular

Share to Neoplasms

Share to Tumor Microenvironment

Source

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Identifiers

PMID: 34594338
DOI: 10.3389/fimmu.2021.734551
PMCID: PMC8476995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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