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Article

Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.

PLoS pathogens - 1 Jan 2012

Dupuy Stéphanie, Lambert Marion, Zucman David, Choukem Siméon-Pierre, Tognarelli Sara, Pages Cécile, Lebbé Céleste, Caillat-Zucman Sophie

Abstract excerpt

The contribution of innate immunity to immunosurveillance of the oncogenic Human Herpes Virus 8 (HHV8) has not been studied in depth. We investigated NK cell phenotype and function in 70 HHV8-infected subjects, either asymptomatic carriers or having developed Kaposi's sarcoma (KS). Our results revealed substantial alterations of the NK cell receptor repertoire in healthy HHV8 carriers, with reduced expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Killer Cells, Natural

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Share to NK Cell Lectin-Like Receptor Subfamily K

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Source

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Identifiers

PMID: 22253598
DOI: 10.1371/journal.ppat.1002486
PMCID: PMC3257307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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