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Article

New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis.

Journal of cell science - 1 Nov 2016

Bastow Emma L, Peswani Amber R, Tarrant Daniel S J, Pentland Daniel R, Chen Xi, Morgan Alan, Staniforth Gemma L, Tullet Jennifer M, Rowe Michelle L, Howard Mark J, Tuite Mick F, Gourlay Campbell W

Abstract excerpt

A number of genes have been linked to familial forms of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Over 150 mutations within the gene encoding superoxide dismutase 1 (SOD1) have been implicated in ALS, but why such mutations lead to ALS-associated cellular dysfunction is unclear. In this study, we identify how ALS-linked SOD1 mutations lead to changes in the cellular health of the yeast...

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Source

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Identifiers

PMID: 27656112
DOI: 10.1242/jcs.190298
PMCID: PMC5117206

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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