Article
A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese.
Human molecular genetics - 1 May 2013
Yang Lei, Liu Bin, Huang Binfang, Deng Jieqiong, Li Hongbin, Yu Bolan, Qiu Fuman, Cheng Mei, Wang Hui, Yang Rongrong, Yang Xiaorong, Zhou Yifeng, Lu Jiachun
Abstract excerpt
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that has been reported to lose function due to genetic alterations in several cancers. WWOX maps to the common chromosomal fragile site FRA16D and several copy number variations (CNVs) were found within this gene. In this study, we investigated the association between the CNVs of WWOX and lung cancer risk in four independent case-control studies,...
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