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Article

Potential for Bias in Studies on Efficacy of Prophylactic Surgery for BRCA1 and BRCA2 Mutation

1 Jul 2003

Abstract excerpt

Women who carry a germline mutation in the BRCA1 or BRCA2 (BRCA1/2) gene have a 50%–80% lifetime risk of developing breast cancer and a 10%–40% lifetime risk of developing ovarian cancer (1–4). These high-risk women are being offered various preventive measures, including surveillance, chemoprevention, and prophylactic surgery to reduce their risk of cancer. During a prophylactic bilateral mastectomy or a...

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PMID: 12837830
DOI: 10.1093/jnci/95.13.941

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Potential for Bias in Studies on Efficacy of Prophylactic Surgery for BRCA1 and BRCA2 MutationPMID 12837830Read ↗

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