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Article

MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.

American journal of respiratory and critical care medicine - 15 Feb 2017

Hong Zhigang, Chen Kuang-Hueih, DasGupta Asish, Potus Francois, Dunham-Snary Kimberly, Bonnet Sebastien, Tian Lian, Fu Jennifer, Breuils-Bonnet Sandra, Provencher Steeve, Wu Danchen, Mewburn Jeffrey, Ormiston Mark L, Archer Stephen L

Abstract excerpt

RATIONALE: Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and apoptosis resistance. This cancer-like phenotype is promoted by increased cytosolic calcium ([Ca2+]cyto), aerobic glycolysis, and mitochondrial fission. OBJECTIVES: To determine how changes in mitochondrial calcium uniporter (MCU)...

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Source

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Identifiers

PMID: 27648837
DOI: 10.1164/rccm.201604-0814OC
PMCID: PMC5378421

Genes

PAH
MCU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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