Article
The mitochondrial calcium uniporter is involved in mitochondrial calcium cycle dysfunction: Underlying mechanism of hypertension associated with mitochondrial tRNA(Ile) A4263G mutation.
The international journal of biochemistry & cell biology - 1 Sept 2016
Chen Xi, Zhang Yu, Xu Bin, Cai Zhongqi, Wang Lin, Tian Jinwen, Liu Yuqi, Li Yang
Abstract excerpt
Recent studies have shown that the mitochondrial DNA mutations are involved in the pathogenesis of hypertension. Our previous study identified mitochondrial tRNA(Ile) A4263G mutation in a large Chinese Han family with maternally-inherited hypertension. This mutation may contribute to mitochondrial Ca(2+) cycling dysfuntion, but the mechanism is unclear. Lymphoblastoid cell lines were derived from hypertensive and...
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