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Article

The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease.

Biochemical and biophysical research communications - 21 Aug 2015

Seifert Erin L, Ligeti Erzsébet, Mayr Johannes A, Sondheimer Neal, Hajnóczky György

Abstract excerpt

The mitochondrial phosphate carrier (PiC) is a mitochondrial solute carrier protein, which is encoded by SLC25A3 in humans. PiC delivers phosphate, a key substrate of oxidative phosphorylation, across the inner mitochondrial membrane. This transport activity is also relevant for allowing effective mitochondrial calcium handling. Furthermore, PiC has also been described to affect cell survival mechanisms via...

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Identifiers

PMID: 26091567
DOI: 10.1016/j.bbrc.2015.06.031
PMCID: PMC8011645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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