Article
Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016
Anil Sukumaran, Gopikrishnan P B, Basheer Ashik Bin, Vidyullatha B G, Alogaibi Yahya A, Chalisserry Elna P, Javed Fawad, Dalati M Hn, Vellappally Sajith, Hashem Mohamed Ibrahim, Divakar Darshan Devang
Abstract excerpt
BACKGROUND: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER)...
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