PARP1 genetic variants modulate gene expression and cervical cancer susceptibility in a North Indian case-control study.

doi:10.1007/s11033-026-12655-4

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Article

PARP1 genetic variants modulate gene expression and cervical cancer susceptibility in a North Indian case-control study.

Molecular biology reports - 27 Aug 2026

Masood Shireen, Rajawat Jyotika, Kumar Madhu, Singh Geeta, Srivastava Kirti, Banerjee Monisha

Abstract excerpt

BACKGROUND: Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear protein involved in the DNA repair pathway. The aim of this investigation was to assess the association of PARP1 polymorphisms with PARP1 expression and cervical cancer susceptibility in North Indian women. METHODS AND RESULTS: This was a case-control study comprised of 141 cervical cancer patients and 147 healthy controls. The PCR-RFLP was performed...

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PMID: 42658306
DOI: 10.1007/s11033-026-12655-4

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PARP1

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