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Glutathione S-transferasesP1 AA (105Ile) allele increases oral cancer risk, interacts strongly with c-Jun Kinase and weakly detoxifies areca-nut metabolites.

Scientific reports - 7 Apr 2020

Yadav Pallavi, Banerjee Atanu, Boruah Nabamita, Singh Chongtham Sovachandra, Chatterjee Puja, Mukherjee Souvik, Dakhar Hughbert, Nongrum Henry B, Bhattacharjee Atanu, Chatterjee Anupam

Abstract excerpt

The Glutathione S-transferases (GSTs) protects cellular DNA against oxidative damage. The role of GSTP1 polymorphism (A313G; Ile105Val) as a susceptibility factor in oral cancer was evaluated in a hospital-based case-control study in North-East India, because the habit of chewing raw areca-nut (RAN) with/without tobacco is common in this region. Genetic polymorphism was investigated by genotyping 445 cases and...

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PMID: 32265484
DOI: 10.1038/s41598-020-63034-3
PMCID: PMC7138809

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