Article
The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype.
Vaccine - 17 Oct 2016
Munier C Mee Ling, van Bockel David, Bailey Michelle, Ip Susanna, Xu Yin, Alcantara Sheilajen, Liu Sue Min, Denyer Gareth, Kaplan Warren, Suzuki Kazuo, Croft Nathan, Purcell Anthony, Tscharke David, Cooper David A, Kent Stephen J, Zaunders John J, Kelleher Anthony D
Abstract excerpt
BACKGROUND: Smallpox was eradicated by a global program of inoculation with Vaccinia virus (VV). Robust VV-specific CD4 T-cell responses during primary infection are likely essential to controlling VV replication. Although there is increasing interest in cytolytic CD4 T-cells across many viral infections, the importance of these cells during acute VV infection is unclear. METHODS: We undertook a detailed...
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