Article
Concurrent generation of effector and central memory CD8 T cells during vaccinia virus infection.
PloS one - 1 Jan 2008
Laouar Amale, Manocha Monika, Haridas Viraga, Manjunath N
Abstract excerpt
It is generally thought that during the contraction phase of an acute anti-viral T cell reponse, the effector T cells that escape activation-induced cell death eventually differentiate into central memory T cells over the next several weeks. Here we report that antigen-specific CD8T cells with the phenotype and function of central memory cells develop concomitantly with effector T cells during vaccinia virus (vv)...
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