Article
Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.
Immunology - 1 Oct 2017
Bhattacharyya Mitra, Madden Patrick, Henning Nathan, Gregory Shana, Aid Malika, Martinot Amanda J, Barouch Dan H, Penaloza-MacMaster Pablo
Abstract excerpt
CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but can induce lethal T helper type 1-driven inflammation. In contrast, memory CD4 T cells exhibit a...
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