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Article

Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2005

Rock Michael T, Yoder Sandra M, Wright Peter F, Talbot Thomas R, Edwards Kathryn M, Crowe James E

Abstract excerpt

Primary immunization of healthy adults with vaccinia virus induces a local vesicle or "take" in the majority of vaccinees that previously has been shown to correlate with protection against smallpox. However, the immunologic mechanisms underlying this protective response in humans are not well characterized. We have studied human CD8+ T cells for the expression patterns of phenotypic markers and cytolytic...

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Source

Identifiers

PMID: 15749916
DOI: 10.4049/jimmunol.174.6.3757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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