Article
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.
Blood - 1 Sept 2005
Zaunders John J, Munier Mee Ling, Kaufmann Daniel E, Ip Susanna, Grey Pat, Smith Don, Ramacciotti Tim, Quan Dick, Finlayson Robert, Kaldor John, Rosenberg Eric S, Walker Bruce D, Cooper David A, Kelleher Anthony D
Abstract excerpt
We investigated whether HIV-1 antigen-specific CD4(+) T cells expressed the viral coreceptor CCR5 during primary HIV-1 infection (PHI). In the peripheral blood of subjects with very early PHI (< 22 days after onset of symptoms), there was a 10- to 20-fold increase in the proportion of highly activated (CD38(+++)) and proliferating (Ki-67(+)) CD4(+) T cells that expressed CCR5(+), and were mostly T-cell...
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