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Article

Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection

24 Sept 2018

Abstract excerpt

Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of antigen-specific responses. Here we describe the first lytic proteome-wide analysis of CD8+ T cell responses to a gamma1-herpesvirus, Epstein-Barr virus (EBV), and...

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PMID: 30248160
DOI: 10.1371/journal.ppat.1007110

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