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Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

24 Feb 2011

Abstract excerpt

The mammalian kidney is composed of thousands of individual epithelial tubules known as nephrons. Deficits in nephron number are associated with myriad diseases ranging from complete organ failure to congenital hypertension. A balance between differentiation and maintenance of a mesenchymal progenitor cell population determines the final number of nephrons. How this balance is struck is poorly understood....

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PMID: 21350016
DOI: 10.1242/dev.057646

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