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Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis

2025-10-31

Abstract excerpt

Pancreas organogenesis relies on sequential interactions between the pancreatic epithelium and surrounding mesodermal cell types that initiate epithelial budding and branching to form a complex ductal network with terminal acini. Despite recent advances with pluripotent stem cell-based approaches, there are no models that robustly recapitulate pancreas morphogenesis or the spatial organization of ductal, exocrine,...

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Literature Corpus work
828a9fcc-6c6a-5f22-8d66-9212b83fc9e2
DOI
10.1101/2025.10.31.685661
Open publication

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Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesisDOI 10.1101/2025.10.31.685661
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