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Article

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells.

Stem cells translational medicine - 1 May 2016

Simsek Senem, Zhou Ting, Robinson Christopher L, Tsai Su-Yi, Crespo Miguel, Amin Sadaf, Lin Xiangyi, Hon Jane, Evans Todd, Chen Shuibing

Abstract excerpt

UNLABELLED: We established an efficient strategy to direct human pluripotent stem cells, including human embryonic stem cells (hESCs) and an induced pluripotent stem cell (iPSC) line derived from patients with cystic fibrosis, to differentiate into pancreatic ductal epithelial cells (PDECs). After purification, more than 98% of hESC-derived PDECs expressed functional cystic fibrosis transmembrane conductance...

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Source

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Identifiers

PMID: 27034411
DOI: 10.5966/sctm.2015-0276
PMCID: PMC4835252

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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