Article
Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent.
Transfusion - 1 Dec 2016
Howie Heather L, Delaney Meghan, Wang Xiaohong, Er Lay See, Vidarsson Gestur, Stegmann Tamara C, Kapp Linda, Lebedev Jenna N, Wu Yanyun, AuBuchon James P, Zimring James C
Abstract excerpt
BACKGROUND: Human immunoglobulin G (IgG) includes four different subtypes (IgG1, IgG2, IgG3, and IgG4), and it is also now appreciated that there are genetic variations within IgG subtypes (called isoallotypes). Twenty-nine different isoallotypes have been described, with 7, 4, 15, and 3 isoallotypes described for IgG1, IgG2, IgG3, and IgG4, respectively. The reactivity of anti-IgG with different isoallotypes has...
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