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Article

Immunoglobulin GM (γ marker) allotypes and their role in immune response and disease susceptibility.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2025

Pandey Janardan P

Abstract excerpt

Immunoglobulin GM (γ marker) allotypes are encoded by 3 very closely linked and highly homologous immunoglobulin heavy chain G (IGHG) genes-IGHG1, IGHG2, and IGHG3-on chromosome 14q32. They are localized on the constant region of γ1, γ2, and γ3 chains. There are currently 18 serologically testable GM specificities. Linkage disequilibrium in the GM system within a racial/ethnic group is almost absolute and the...

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Identifiers

PMID: 40795249
DOI: 10.1093/jimmun/vkaf190
PMCID: PMC12726066

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