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Article

Rapid LC-MS screening for IgG Fc modifications and allelic variants in blood.

Molecular immunology - 1 Oct 2011

Goetze Andrew M, Zhang Zhongqi, Liu Ling, Jacobsen Frederick W, Flynn Gregory C

Abstract excerpt

A new method for simultaneously screening allelic variants and certain Fc modifications on endogenous human IgG1 and IgG2 directly from blood samples is described. The IdeS endoproteinase was used to cleave IgG in serum to generate Fc, which, after denaturation, was analyzed directly as monomeric Fc (Fc/2) by LC-MS to identify the haplotype(s) present in each individual. The relative levels of IgG isotype and...

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Share to Blood Chemical Analysis
Share to Chromatography, Liquid
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21945018
DOI: 10.1016/j.molimm.2011.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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