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Article

Optimized Multiplex Detection of 7 KRAS Mutations by Taqman Allele-Specific qPCR.

PloS one - 1 Jan 2016

Orue Andrea, Rieber Manuel

Abstract excerpt

UNLABELLED: Establishing the KRAS mutational status of tumor samples is essential to manage patients with colorectal or lung cancer, since these mutations preclude treatment with monoclonal anti-epidermal growth factor receptor (EGFR) antibodies. We report an inexpensive, rapid multiplex allele-specific qPCR method detecting the 7 most clinically relevant KRAS somatic mutations with concomitant amplification of...

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Source

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Identifiers

PMID: 27632281
DOI: 10.1371/journal.pone.0163070
PMCID: PMC5025196

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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