Article
The usability of allele-specific PCR and reverse-hybridization assays for KRAS genotyping in Serbian colorectal cancer patients.
Digestive diseases and sciences - 1 Apr 2013
Brotto Ksenija, Malisic Emina, Cavic Milena, Krivokuca Ana, Jankovic Radmila
Abstract excerpt
BACKGROUND: Colorectal cancers (CRCs) with wild-type KRAS respond to EGFR-targeted antibody treatment. Analysis of the hotspot clustered mutations in codons 12 and 13 is compulsory before therapy and no standardized methodology for that purpose has been established so far. Since these mutations may have different biological effects and clinical outcome, reliable frequency and types of KRAS mutations need to be...
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