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Article

High-Resolution Expression Profiling of Peripheral Blood CD8+ Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution.

Molecular neurobiology - 1 Sept 2017

Roch Luisa, Hecker Michael, Friess Jörg, Angerer Ines Charlotte, Koczan Dirk, Fitzner Brit, Schröder Ina, Flechtner Kristin, Thiesen Hans-Jürgen, Meister Stefanie, Winkelmann Alexander, Zettl Uwe Klaus

Abstract excerpt

Fingolimod, a sphingosine-1-phosphate (S1P) receptor modulator, is an oral drug approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). It selectively inhibits the egress of lymphocytes from lymph nodes. We studied the changes in the transcriptome of peripheral blood CD8+ cells to unravel the effects at the molecular level during fingolimod therapy. We separated CD8+ cells from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27631876
DOI: 10.1007/s12035-016-0075-0

Genes

CCR7
MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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