Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS

22 Jan 2014

Abstract excerpt

OBJECTIVE: Our objective was to determine whether altered naive CD4 T-cell biology contributes to development of disease progression in secondary progressive multiple sclerosis (SPMS). METHODS: We compared the naive CD4 T-cell gene expression profiles of 19 patients with SPMS and 14 healthy controls (HCs) using a whole-genome microarray approach. We analyzed surface protein expression of critical genes by flow...

Topics

Join the communities discussing this publication.

Immunotherapy and Immune Responses
Multiple Sclerosis Research Studies
T-cell and B-cell Immunology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24453076
DOI: 10.1212/wnl.0000000000000146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MSPMID 24453076Read ↗

Global transcriptome profiling of mild relapsing‐remitting versus primary progressive multiple sclerosisSemantic proximity Read ↗

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosisSemantic proximity Read ↗

Dysregulation of MS risk genes and pathways at distinct stages of diseaseSemantic proximity Read ↗

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation stateSemantic proximity Read ↗

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosisSemantic proximity Read ↗

Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencingSemantic proximity Read ↗

Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicitySemantic proximity Read ↗

Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosisSemantic proximity Read ↗

Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cellsSemantic proximity Read ↗

Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosisSemantic proximity Read ↗

Quantitative Proteomics Reveals Protein Dysregulation During T Cell Activation in Multiple Sclerosis Patients Compared to Healthy ControlsSemantic proximity Read ↗

Immune Cell Heterogeneity in Multiple Sclerosis Reveals Myeloid-Specific Dysfunction and Distinct Regulatory Programs Across CD14+, CD4+, and CD8+ Immune CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.